Peptide EncyclopediaA clinical monograph on orforglipron — the first oral, non-peptide small-molecule GLP-1 receptor agonist, FDA-approved as Foundayo in 2026 for chronic weight management, with Grade A Phase 3 RCT evidence.
Peptide Encyclopedia11 MIN READ
Peptide EncyclopediaA clinical monograph on retatrutide (LY3437943) — Eli Lilly's investigational triple GIP/GLP-1/glucagon agonist with the largest pharmacologic weight loss reported to date, graded A on human Phase 3 RCTs, but FDA-unapproved and WADA-prohibited as of mid-2026.
Peptide Encyclopedia12 MIN READ
Peptide EncyclopediaA clinical monograph on mazdutide (IBI362 / LY3305677) — the first GLP-1/glucagon dual receptor agonist, backed by completed Phase 3 RCTs for obesity and type 2 diabetes, approved in China but investigational in the US.
Peptide Encyclopedia12 MIN READ
Peptide EncyclopediaA clinical monograph on lixisenatide (Adlyxin/Lyxumia) — the short-acting, exendin-4-derived GLP-1 receptor agonist for type 2 diabetes, with a large RCT base, proven cardiovascular safety, and an emerging Parkinson's signal.
Peptide Encyclopedia11 MIN READ
Peptide EncyclopediaA clinical monograph on liraglutide — the once-daily GLP-1 receptor agonist sold as Victoza and Saxenda. Grade A human RCT evidence for glycemic control, weight loss, and reduced cardiovascular death.
Peptide Encyclopedia12 MIN READ
Peptide EncyclopediaA clinical monograph on exenatide — the first-in-class GLP-1 receptor agonist (synthetic exendin-4) — with a focus on its Grade A pediatric type 2 diabetes evidence, mechanism, dosing from the literature, safety, and 2026 regulatory status.
Peptide Encyclopedia11 MIN READ
Peptide EncyclopediaA clinical monograph on dulaglutide (Trulicity) — the once-weekly GLP-1-Fc fusion biologic with Grade A human RCT evidence for glycemic control and a 12% cardiovascular event reduction.
Peptide Encyclopedia11 MIN READ