Libido, erectile, hormone-axis and fertility peptides — approved and experimental.
Sexual & Hormonal Health covers peptides for libido in both sexes, erectile function, testosterone and growth-hormone optimization, menopause and fertility. It spans FDA-approved agents like PT-141 (bremelanotide) and fertility-axis peptides through to high-risk gray-market compounds — and we separate the approved from the experimental and the dangerous.
The peptides with real human evidence for raising or protecting endogenous testosterone are the classical reproductive gonadotropins — hCG and LH/FSH — not the boutique 'natural testosterone' research peptides. A ranked, evidence-graded review for 2026.
A cross-sex, evidence-first overview of the peptides studied for sexual desire, arousal and erectile function — bremelanotide, kisspeptin, melanotan II and oxytocin — graded honestly for men and women. Only one is FDA-approved.
Sexual & Hormonal HealthA clinical, evidence-first ranking of the peptides marketed for the menopause transition — separating the one FDA-approved molecule from the population-borrowed, preclinical, and mechanistically backwards claims.
Sexual & Hormonal HealthA clinical-editorial ranking of the peptides studied for low sexual desire in women — bremelanotide (PT-141/Vyleesi), kisspeptin and oxytocin — graded honestly. Only one is FDA-approved, and even that is a modest, as-needed tool.
Sexual & Hormonal HealthA clinical-editorial ranking of the peptides studied for male low libido — PT-141, kisspeptin and gonadorelin — graded honestly. The strongest evidence for male desire is correcting low testosterone, not a peptide.
Sexual & Hormonal HealthAn evidence-first ranking of the GH secretagogues sold for 'growth hormone optimization' — tesamorelin, MK-677, CJC-1295, sermorelin and ipamorelin — separating what raises GH/IGF-1 in humans from what only sounds like it should.
Sexual & Hormonal HealthThe honest fertility-peptide record: the strongest evidence belongs to the prescription reproductive hormones already in every IVF clinic — hCG, gonadotropins, gonadorelin — plus one investigational frontier, kisspeptin. No over-the-counter research peptide has human fertility data.
Sexual & Hormonal HealthA clinical-editorial ranking of the peptides studied for erectile dysfunction — melanocortin agents (PT-141, melanotan-2) and kisspeptin — graded honestly against the AUA first-line standard. No peptide is FDA-approved for ED.
Yes — PT-141 (bremelanotide, brand name Vyleesi) is FDA-approved for premenopausal hypoactive sexual desire disorder, supported by the RECONNECT pivotal trials. It is a melanocortin-4-receptor agonist used on-demand. We grade its approved indication A. Its off-label use for male libido and erectile function is less well-evidenced, and we note the difference, along with its side-effect profile (nausea, transient blood-pressure rise, hyperpigmentation).
Melanotan II is a non-selective melanocortin agonist sold on the gray market for tanning, libido and appetite effects, with essentially anecdotal human evidence and a serious safety profile: nausea, priapism, new or changing moles, melanoma case reports and rhabdomyolysis. It is not FDA-approved and is expected to remain restricted. We flag it as high-risk and treat its monograph as a harm-reduction warning, not an endorsement.
Gonadorelin (a GnRH analog) and hCG are used as adjuncts to testosterone therapy to help maintain intratesticular testosterone, testicular volume and fertility, an application with a clinical rationale and some supporting evidence. hCG is FDA-approved for fertility indications. We explain the mechanism and evidence, but this is informational — fertility and hormone-axis management belongs with an endocrinologist or urologist, not a self-directed peptide protocol.
The majority of compounds documented here are not approved by the FDA for human use. Approved drugs (e.g. semaglutide, tirzepatide) are noted explicitly and require a licensed prescriber.
Many peptides — including BPC-157 and GHK-Cu in injectable form — are sold strictly "for research use only — not for human consumption." Purity, identity, and dosing of such products are not regulated or guaranteed.
Several compounds are banned in competitive sport under the WADA Prohibited List. Athletes risk sanction regardless of intent or formulation.
Always consult a qualified, licensed healthcare professional before considering any compound. Individual risk depends on your full medical context.
This content is for informational and educational purposes only · No physician–patient relationship is created · Evidence grades reflect published data as of the stated revision and may change.
